1 High Alert enoxaparin (e-nox-a-pa-rin) Lovenox Classification Therapeutic: anticoagulants Pharmacologic: antithrombotics, heparins (low molecular weight) Pregnancy Category B Indications Prevention of venous thromboembolism (VTE) (deep vein thrombosis (DVT) and/or pulmonary embolism (PE)) in surgical or medical patients. Treatment of DVT with or without PE (with warfarin). Prevention of ischemic complications (with aspirin) from unstable angina and non-ST-segment-elevation MI. Treatment of acute ST-segment- elevation MI (with thrombolytics or percutaneous coronary intervention). Action Potentiates the inhibitory effect of antithrombin on factor Xa and thrombin. Therapeutic Effects: Prevention of thrombus formation. Pharmacokinetics Absorption: 100% absorbed after subcut administration. Distribution: Unknown. Metabolism and Excretion: Metabolized in the liver, primarily renally eliminated Clearancepby 30% in renal impairment (CCr 30 ml/min). Half-life: Single dose: 4.5 hr; Repeat dos
